Hydromethylation of Unactivated Olefins.

ABSTRACT: A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly "edit" complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.

SUBMITTER: Dao HT 

PROVIDER: S-EPMC4490774 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature