Ontology highlight
ABSTRACT:
SUBMITTER: Dao HT
PROVIDER: S-EPMC4490774 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20150619 25
A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly "edit" complex natural products and other advanced materials. The method is also amenable t ...[more]