Ontology highlight
ABSTRACT:
SUBMITTER: Arias-Palomo E
PROVIDER: S-EPMC4537775 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Arias-Palomo Ernesto E Berger James M JM
Cell 20150801 4
Transposons are ubiquitous genetic elements that drive genome rearrangements, evolution, and the spread of infectious disease and drug-resistance. Many transposons, such as Mu, Tn7, and IS21, require regulatory AAA+ ATPases for function. We use X-ray crystallography and cryo-electron microscopy to show that the ATPase subunit of IS21, IstB, assembles into a clamshell-shaped decamer that sandwiches DNA between two helical pentamers of ATP-associated AAA+ domains, sharply bending the duplex into a ...[more]