Unknown

Dataset Information

0

Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.


ABSTRACT: A novel New Delhi metallo-?-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against ?-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher k cat/Km ratios for cefotaxime. The genetic environment of bla NDM-13 was determined to be tnpA-IS30-bla NDM-13-ble MBL-trpF-dsbC-cutA-groES-groL, with bla NDM-13 located within the chromosome.

SUBMITTER: Shrestha B 

PROVIDER: S-EPMC4538491 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.

Shrestha Basudha B   Tada Tatsuya T   Miyoshi-Akiyama Tohru T   Shimada Kayo K   Ohara Hiroshi H   Kirikae Teruo T   Pokhrel Bharat M BM  

Antimicrobial agents and chemotherapy 20150713 9


A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher k cat/Km ratios for cefotaxime. The genetic environment of bla NDM-13 was determined to be tnpA-IS30-bla NDM-13-ble MBL-trpF-dsbC-cutA-groES-groL, with bla NDM-13 located within the chromosome. ...[more]

Similar Datasets

| S-EPMC4187903 | biostudies-literature
| S-EPMC3632942 | biostudies-literature
| S-EPMC3232805 | biostudies-literature
| S-EPMC3868851 | biostudies-literature
| S-EPMC2976126 | biostudies-literature
| S-EPMC4135848 | biostudies-literature
| S-EPMC7441242 | biostudies-literature
| S-EPMC8513677 | biostudies-literature
| S-EPMC7320882 | biostudies-literature
| S-EPMC4823973 | biostudies-literature