Ontology highlight
ABSTRACT:
SUBMITTER: Izumchenko E
PROVIDER: S-EPMC4595648 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Izumchenko Evgeny E Chang Xiaofei X Brait Mariana M Fertig Elana E Kagohara Luciane T LT Bedi Atul A Marchionni Luigi L Agrawal Nishant N Ravi Rajani R Jones Sian S Hoque Mohammad O MO Westra William H WH Sidransky David D
Nature communications 20150916
Lungs resected for adenocarcinomas often harbour minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia (AAH). Evidence suggests that AAH represents an initial step in the progression to adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and fully invasive adenocarcinoma. Despite efforts to identify predictive markers of malignant transformation, alterations driving this progression are poorly understood. Here we ...[more]