Ontology highlight
ABSTRACT:
SUBMITTER: Zhu J
PROVIDER: S-EPMC4613663 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhu Jiayun J Su Fengtao F Mukherjee Shibani S Mori Eiichiro E Hu Burong B Asaithamby Aroumougame A
Cell cycle (Georgetown, Tex.) 20150101 12
Fanconi Anemia (FA) is a cancer predisposition syndrome and the factors defective in FA are involved in DNA replication, DNA damage repair and tumor suppression. Here, we show that FANCD2 is critical for genome stability maintenance in response to high-linear energy transfer (LET) radiation. We found that FANCD2 is monoubiquitinated and recruited to the sites of clustered DNA double-stranded breaks (DSBs) specifically in S/G2 cells after high-LET radiation. Further, FANCD2 facilitated the repair ...[more]