Ontology highlight
ABSTRACT:
SUBMITTER: Purcell M
PROVIDER: S-EPMC4615143 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Purcell Maggie M Kruger Adele A Tainsky Michael A MA
Cell cycle (Georgetown, Tex.) 20140101 24
Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism. Senescence can be a result of telomere shortening (natural or replicative senescence) or DNA damage resulting from exogenous stressors (induced senescence). Here, we performed gene expression profiling through RNA-seq of replicative senescence, adriamycin-induced senescence, H2O2-induced senescen ...[more]