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Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32.

ABSTRACT: Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5-7, and 9-12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher's and Marfey's methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4-6 and 8-12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds.

SUBMITTER: Fan YQ

PROVIDER: S-EPMC4626702 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32.

Fan Ya-Qin YQ Li Pei-Hai PH Chao Ya-Xi YX Chen Hao H Du Ning N He Qiu-Xia QX Liu Ke-Chun KC

Marine drugs 20151022 10

Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5-7, and 9-12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher's and Marfey's methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative ef ...[more]

PMID: 26506361

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