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Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.

ABSTRACT: Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.

SUBMITTER: Zhu S

PROVIDER: S-EPMC4633528 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.

Zhu Suwei S Nih Lina L Carmichael S Thomas ST Lu Yunfeng Y Segura Tatiana T

Advanced materials (Deerfield Beach, Fla.) 20150512 24

Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing. ...[more]

PMID: 25962336

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