Ontology highlight
ABSTRACT:
SUBMITTER: Brandt JP
PROVIDER: S-EPMC4642686 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Current biology : CB 20150813 17
Toll-like receptors (TLRs) play critical roles in innate immunity in many animal species. The sole TLR of C. elegans--TOL-1--is required for a pathogen-avoidance behavior, yet how it promotes this behavior is unknown. We show that for pathogen avoidance TOL-1 signaling is required in the chemosensory BAG neurons, where it regulates gene expression and is necessary for their chemosensory function. Genetic studies revealed that TOL-1 acts together with many conserved components of TLR signaling. B ...[more]