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Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons.

ABSTRACT: The commonly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the C?H activation of amines for the first time. An enantioselective ortho-C?H cross-coupling between nosyl-protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono-N-protected amino acid (MPAA) ligands as a promoter.

SUBMITTER: Laforteza BN

PROVIDER: S-EPMC4642891 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons.

Laforteza Brian N BN Chan Kelvin S L KS Yu Jin-Quan JQ

Angewandte Chemie (International ed. in English) 20150804 38

The commonly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation of amines for the first time. An enantioselective ortho-CH cross-coupling between nosyl-protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono-N-protected amino acid (MPAA) ligands as a promoter. ...[more]

PMID: 26242903

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