Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC4655822 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Zhao Zhen Z Nelson Amy R AR Betsholtz Christer C Zlokovic Berislav V BV
Cell 20151101 5
Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurologic ...[more]