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Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy.

ABSTRACT: T regulatory cells (Tregs) are subsets of T lymphocytes specialized in modulating antigen-specific immune responses in vivo. Hence, Tregs represent an ideal therapeutic tool to control detrimental immune reactions. Based on solid pre-clinical results, investigators started testing the safety and efficacy of Treg-based therapies in humans. Despite promising results, a number of issues remain to be solved. We will discuss the results obtained from clinical trials and the challenges and risks we are facing in the further development of Treg-based therapies.

SUBMITTER: Gregori S

PROVIDER: S-EPMC4658444 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy.

Gregori Silvia S Passerini Laura L Roncarolo Maria-Grazia MG

Frontiers in immunology 20151125

T regulatory cells (Tregs) are subsets of T lymphocytes specialized in modulating antigen-specific immune responses in vivo. Hence, Tregs represent an ideal therapeutic tool to control detrimental immune reactions. Based on solid pre-clinical results, investigators started testing the safety and efficacy of Treg-based therapies in humans. Despite promising results, a number of issues remain to be solved. We will discuss the results obtained from clinical trials and the challenges and risks we ar ...[more]

PMID: 26635807

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