Ontology highlight
ABSTRACT:
SUBMITTER: Pan D
PROVIDER: S-EPMC4679478 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Developmental cell 20151125 5
Progression from brown preadipocytes to adipocytes engages two transcriptional programs: the expression of adipogenic genes common to both brown fat (BAT) and white fat (WAT), and the expression of BAT-selective genes. However, the dynamics of chromatin states and epigenetic enzymes involved remain poorly understood. Here we show that BAT development is selectively marked and guided by repressive H3K27me3 and is executed by its demethylase Jmjd3. We find that a significant subset of BAT-selectiv ...[more]