Ontology highlight
ABSTRACT:
SUBMITTER: Kasar S
PROVIDER: S-EPMC4686820 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Kasar S S Kim J J Improgo R R Tiao G G Polak P P Haradhvala N N Lawrence M S MS Kiezun A A Fernandes S M SM Bahl S S Sougnez C C Gabriel S S Lander E S ES Kim H T HT Getz G G Brown J R JR
Nature communications 20151207
Patients with chromosome 13q deletion or normal cytogenetics represent the majority of chronic lymphocytic leukaemia (CLL) cases, yet have relatively few driver mutations. To better understand their genomic landscape, here we perform whole-genome sequencing on a cohort of patients enriched with these cytogenetic characteristics. Mutations in known CLL drivers are seen in only 33% of this cohort, and associated with normal cytogenetics and unmutated IGHV. The most commonly mutated gene in our coh ...[more]