Ontology highlight
ABSTRACT:
SUBMITTER: Wu JX
PROVIDER: S-EPMC4686854 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Wu Jing-Xiang JX Cheng Yun-Sheng YS Wang Jue J Chen Lei L Ding Mei M Wu Jia-Wei JW
Nature communications 20151202
The SAD/BRSK kinases participate in various important life processes, including neural development, cell cycle and energy metabolism. Like other members of the AMPK family, SAD contains an N-terminal kinase domain followed by the characteristic UBA and KA1 domains. Here we identify a unique autoinhibitory sequence (AIS) in SAD kinases, which exerts autoregulation in cooperation with UBA. Structural studies of mouse SAD-A revealed that UBA binds to the kinase domain in a distinct mode and, more i ...[more]