Ontology highlight
ABSTRACT:
SUBMITTER: Zheng J
PROVIDER: S-EPMC4692268 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20150921 45
The first trifluoromethylthiolation and [(18)F]trifluoromethylthiolation of alkyl electrophiles with in situ generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition-metal-free approach is high yielding, compatible with a variety of functional groups, and operated under mild reaction conditions. The conceptual advantage of this exogenous-fluoride-mediated transformation enables unprecedented syntheses of [(18)F]CF3S-label ...[more]