Dataset Information
Oxidation of difluorocarbene and subsequent trifluoromethoxylation.
Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC6877537 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Oxidation of difluorocarbene and subsequent trifluoromethoxylation.
Nature communications 20191125 1
As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, <sup>18</sup>O-trifluoromethoxylation, the observation of AgOCF<sub>3</sub> species, and DFT calculations. ...[more]