Ontology highlight
ABSTRACT:
SUBMITTER: Thoonen R
PROVIDER: S-EPMC4699393 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature communications 20151007
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. Apo-sGC mice are viable and develop hypertension. The haemodynamic effects of NO are abolished, but those of the sGC activator cinaciguat are enhanced in apo-sGC mice, suggesting that the effects of NO on smooth muscle relaxation, blood pressure regu ...[more]