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Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.

ABSTRACT: Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.

SUBMITTER: Gileadi O 

PROVIDER: S-EPMC3901396 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.

Gileadi Opher O  

Biochemical Society transactions 20140201 1

Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention. ...[more]

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