Ontology highlight
ABSTRACT:
SUBMITTER: Rogers NM
PROVIDER: S-EPMC3983488 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rogers Natasha M NM Seeger Franziska F Garcin Elsa D ED Roberts David D DD Isenberg Jeffrey S JS
Frontiers in physiology 20140404
Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators of sGC are being actively pursued as therapies for acute heart failure and pulmonary hypertension. Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular prote ...[more]