Ontology highlight
ABSTRACT:
SUBMITTER: Janssen L
PROVIDER: S-EPMC4700087 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Janssen Lauriane L Dupont Laura L Bekhouche Mourad M Noel Agnès A Leduc Cédric C Voz Marianne M Peers Bernard B Cataldo Didier D Apte Suneel S SS Dubail Johanne J Colige Alain A
Angiogenesis 20151007 1
The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3(+/-) mice were viable and fertile, but their intercrosses demonstrated lethal ...[more]