Ontology highlight
ABSTRACT:
SUBMITTER: Mak AC
PROVIDER: S-EPMC4701098 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Genetics 20151028 1
Comprehensive whole-genome structural variation detection is challenging with current approaches. With diploid cells as DNA source and the presence of numerous repetitive elements, short-read DNA sequencing cannot be used to detect structural variation efficiently. In this report, we show that genome mapping with long, fluorescently labeled DNA molecules imaged on nanochannel arrays can be used for whole-genome structural variation detection without sequencing. While whole-genome haplotyping is ...[more]