Quantitative assessments of glycolysis from single cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Shin YS
PROVIDER: S-EPMC4728151 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Quantitative assessments of glycolysis from single cells.
Shin Young Shik YS Kim Jungwoo J Johnson Dazy D Dooraghi Alex A AA Mai Wilson X WX Ta Lisa L Chatziioannou Arion F AF Phelps Michael E ME Nathanson David A DA Heath James R JR
Technology 20150625 4
The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose (<sup>18</sup>F-FDG). We report on an integrated microfluidics-chip/beta particle imaging system for <i>in vitro</i><sup>18</sup>F-FDG radioassays of glycolysis with single cell resolution. We investigated the kinetic responses of single glioblastoma cancer cells to targeted inhibitors of receptor tyrosine kinase sig ...[more]
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