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One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes.

ABSTRACT: A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.

SUBMITTER: Maslivetc VA

PROVIDER: S-EPMC4749319 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes.

Maslivetc Vladimir A VA Rubina Marina M Rubin Michael M

Organic & biomolecular chemistry 20150805 34

A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates. ...[more]

PMID: 26243009

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