Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC4751545 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
G3 (Bethesda, Md.) 20151123 2
The conserved chromatin remodeling and assembly factor CHD1 (chromodomains, helicase, DNA-binding domain) is present at active genes where it participates in histone turnover and recycling during transcription. In order to gain a more complete understanding of the mechanism of action of CHD1 during development, we created a novel genetic assay in Drosophila melanogaster to evaluate potential functional interactions between CHD1 and other chromatin factors. We found that overexpression of CHD1 re ...[more]