Ontology highlight
ABSTRACT:
SUBMITTER: Kainz QM
PROVIDER: S-EPMC4770572 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kainz Quirin M QM Matier Carson D CD Bartoszewicz Agnieszka A Zultanski Susan L SL Peters Jonas C JC Fu Gregory C GC
Science (New York, N.Y.) 20160201 6274
Despite a well-developed and growing body of work in copper catalysis, the potential of copper to serve as a photocatalyst remains underexplored. Here we describe a photoinduced copper-catalyzed method for coupling readily available racemic tertiary alkyl chloride electrophiles with amines to generate fully substituted stereocenters with high enantioselectivity. The reaction proceeds at -40°C under excitation by a blue light-emitting diode and benefits from the use of a single, Earth-abundant tr ...[more]