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Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of A? Plaques in Alzheimer's Disease.

ABSTRACT: Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (A?) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to A? plaques which is a hallmark of AD. To address this binding, we have designed a novel nanoimaging agent (NIA) based on nature-derived poly(?-l-malic acid) (PMLA) containing covalently attached gadolinium-DOTA(Gd-DOTA) and nature-derived CUR. The all-in-one agent recognizes and selectively binds to A? plaques and is detected by MRI. It efficiently detected A? plaques in human and mouse samples by an ex vivo staining. The method can be useful in clinic for safe and noninvasive diagnosis of AD.

SUBMITTER: Patil R 

PROVIDER: S-EPMC4794283 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease.

Patil Rameshwar R   Gangalum Pallavi R PR   Wagner Shawn S   Portilla-Arias Jose J   Ding Hui H   Rekechenetskiy Arthur A   Konda Bindu B   Inoue Satoshi S   Black Keith L KL   Ljubimova Julia Y JY   Holler Eggehard E  

Macromolecular bioscience 20150602 9

Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to Aβ plaques which is a hallmark of AD. To address this binding, we have designed a novel nanoimaging agent (NIA) based on nature-derived poly(β-l-malic acid) (PMLA) containing coval  ...[more]

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