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A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides.

ABSTRACT: Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10?M.

SUBMITTER: Wang K

PROVIDER: S-EPMC4797929 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides.

Wang Ke K Friscourt Frédéric F Dai Chaofeng C Wang Lifang L Zheng Yueqin Y Boons Geert-Jan GJ Wang Siming S Wang Binghe B

Bioorganic & medicinal chemistry letters 20160223 7

Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other commo ...[more]

PMID: 26944613

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