Ontology highlight
ABSTRACT:
SUBMITTER: Behrens AJ
PROVIDER: S-EPMC4805854 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cell reports 20160310 11
The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. The high density of glycans on the trimer surface imposes steric constraints limiting the actions of glycan-processing enzymes, so that multiple under-processed structures remain on specific areas. These oligomannose glycans are recognized by broadly neutralizing antibodies (bNAbs) that are not thwarted by the glycan shield but, paradoxically, target it. Our site-specific gl ...[more]