Ontology highlight
ABSTRACT:
SUBMITTER: Marold JD
PROVIDER: S-EPMC4811334 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Marold Jacob D JD Kavran Jennifer M JM Bowman Gregory D GD Barrick Doug D
Structure (London, England : 1993) 20151001 11
Linear repeat proteins often have high structural similarity and low (∼25%) pairwise sequence identities (PSI) among modules. We identified a unique P. anserina (Pa) sequence with tetratricopeptide repeat (TPR) homology, which contains longer (42 residue) repeats (42PRs) with an average PSI >91%. We determined the crystal structure of five tandem Pa 42PRs to 1.6 Å, and examined the stability and solution properties of constructs containing three to six Pa 42PRs. Compared with 34-residue TPRs (34 ...[more]