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A Mild and General One-Pot Synthesis of Densely Functionalized Diaryliodonium Salts.

ABSTRACT: Diaryliodonium salts are powerful and widely used arylating agents in organic chemistry. Here we report a scalable, synthesis of densely functionalized diaryliodonium salts from aryl iodides under mild conditions. This two-step, one-pot process has remarkable functional group tolerance, is compatible with commonly employed acid-labile protective group strategies, avoids heavy metal and transition metal reagents, and provides a direct route to stable precursors to PET imaging agents.

SUBMITTER: Qin L

PROVIDER: S-EPMC4824678 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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A Mild and General One-Pot Synthesis of Densely Functionalized Diaryliodonium Salts.

Qin Linlin L Hu Bao B Neumann Kiel D KD Linstad Ethan J EJ McCauley Katelyenn K Veness Jordan J Kempinger Jayson J JJ DiMagno Stephen G SG

European journal of organic chemistry 20150814 27

Diaryliodonium salts are powerful and widely used arylating agents in organic chemistry. Here we report a scalable, synthesis of densely functionalized diaryliodonium salts from aryl iodides under mild conditions. This two-step, one-pot process has remarkable functional group tolerance, is compatible with commonly employed acid-labile protective group strategies, avoids heavy metal and transition metal reagents, and provides a direct route to stable precursors to PET imaging agents. ...[more]

PMID: 27065751

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