Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC7283261 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20200609 1
The first catalyst-free post-Ugi cascade methodology was developed for expeditious access to structurally diverse and complex pyrazole-pyrazines in one-pot. This novel cascade reaction features an intramolecular N2-arylation of pyrazoles with allenes at the C-β position of triple bond. Screening in the colorectal cancer cell lines HCT116 and SW620 validated the feasibility of the methodology for generating bioactive compounds. The lead compound 7h which is active against HCT116 and SW620 with IC ...[more]