Synthesis of a stable and orally bioavailable englerin analogue.
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ABSTRACT:
SUBMITTER: Fash DM
PROVIDER: S-EPMC4862412 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Synthesis of a stable and orally bioavailable englerin analogue.
Fash David M DM Peer Cody J CJ Li Zhenwu Z Talisman Ian J IJ Hayavi Sima S Sulzmaier Florian J FJ Ramos Joe W JW Sourbier Carole C Neckers Leonard L Figg W Douglas WD Beutler John A JA Chain William J WJ
Bioorganic & medicinal chemistry letters 20160408 11
Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice. ...[more]
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