Ontology highlight
ABSTRACT:
SUBMITTER: Cai X
PROVIDER: S-EPMC4878021 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cai Xinming X Xu Yongyao Y Cheung Atwood K AK Tomlinson Ronald C RC Alcázar-Román Abel A Murphy Leon L Billich Andreas A Zhang Bailin B Feng Yan Y Klumpp Martin M Rondeau Jean-Michel JM Fazal Aleem N AN Wilson Christopher J CJ Myer Vic V Joberty Gerard G Bouwmeester Tewis T Labow Mark A MA Finan Peter M PM Porter Jeffrey A JA Ploegh Hidde L HL Baird Daniel D De Camilli Pietro P Tallarico John A JA Huang Qian Q
Chemistry & biology 20130701 7
Toll-like receptor (TLR) signaling is a key component of innate immunity. Aberrant TLR activation leads to immune disorders via dysregulation of cytokine production, such as IL-12/IL-23. Herein, we identify and characterize PIKfyve, a lipid kinase, as a critical player in TLR signaling using apilimod as an affinity tool. Apilimod is a potent small molecular inhibitor of IL-12/IL-23 with an unknown target and has been evaluated in clinical trials for patients with Crohn's disease or rheumatoid ar ...[more]