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MicroRNAs in cancer therapeutics: "from the bench to the bedside".

ABSTRACT: MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate physiological processes by targeting proteins directly. Their involvement in research has been robust, and evidence of their regulative functions has granted them the title: master regulators of the human genome. In cancer, they are considered important therapeutic agents, due to the fact that their aberrant expression contributes to disease development, progression, metastasis, therapeutic response and patient overall survival. This has endeavored fields of biomedical sciences to invest in developing and exploiting miRNA-based therapeutics thoroughly. Herein we highlight relevant ongoing/open clinical trials involving miRNAs and cancer.

SUBMITTER: Monroig-Bosque Pdel C

PROVIDER: S-EPMC4890620 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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MicroRNAs in cancer therapeutics: "from the bench to the bedside".

Monroig-Bosque Paloma del C Pdel C Rivera Carlos A CA Calin George A GA Calin George A GA

Expert opinion on biological therapy 20150101 10

MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate physiological processes by targeting proteins directly. Their involvement in research has been robust, and evidence of their regulative functions has granted them the title: master regulators of the human genome. In cancer, they are considered important therapeutic agents, due to the fact that their aberrant expression contributes to disease development, progression, metastasis, therapeutic response and patient overall survival. Thi ...[more]

PMID: 26372796

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