Ontology highlight
ABSTRACT:
SUBMITTER: Mets E
PROVIDER: S-EPMC4890642 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Mets E E Van der Meulen J J Van der Meulen J J Van Peer G G Boice M M Mestdagh P P Van de Walle I I Lammens T T Goossens S S De Moerloose B B Benoit Y Y Van Roy N N Clappier E E Poppe B B Vandesompele J J Wendel H-G HG Taghon T T Rondou P P Soulier J J Van Vlierberghe P P Speleman F F
Leukemia 20140918 4
The MYB oncogene is a leucine zipper transcription factor essential for normal and malignant hematopoiesis. In T-cell acute lymphoblastic leukemia (T-ALL), elevated MYB levels can arise directly through T-cell receptor-mediated MYB translocations, genomic MYB duplications or enhanced TAL1 complex binding at the MYB locus or indirectly through the TAL1/miR-223/FBXW7 regulatory axis. In this study, we used an unbiased MYB 3'untranslated region-microRNA (miRNA) library screen and identified 33 puta ...[more]