Ontology highlight
ABSTRACT:
SUBMITTER: Shaw LA
PROVIDER: S-EPMC4915968 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature immunology 20160523 7
The differentiation of helper T cells into effector subsets is critical to host protection. Transcription factors of the E-protein and Id families are important arbiters of T cell development, but their role in the differentiation of the TH1 and TFH subsets of helper T cells is not well understood. Here, TH1 cells showed more robust Id2 expression than that of TFH cells, and depletion of Id2 via RNA-mediated interference increased the frequency of TFH cells. Furthermore, TH1 differentiation was ...[more]