Ontology highlight
ABSTRACT:
SUBMITTER: Nakayamada S
PROVIDER: S-EPMC3244883 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Nakayamada Shingo S Kanno Yuka Y Takahashi Hayato H Jankovic Dragana D Lu Kristina T KT Johnson Thomas A TA Sun Hong-wei HW Vahedi Golnaz G Hakim Ofir O Handon Robin R Schwartzberg Pamela L PL Hager Gordon L GL O'Shea John J JJ
Immunity 20111201 6
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells. However, STAT4 also induced the transcription factor T-bet. With ChIP-seq, we defined the genome-wide targets of T-bet and found that it repressed Bcl6 and other markers ...[more]