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Influence of backbone conformational rigidity in temperature-sensitive amphiphilic supramolecular assemblies.

ABSTRACT: Molecular design features that endow amphiphilic supramolecular assemblies with a unique temperature-sensitive transition have been investigated. We find that conformational rigidity in the backbone is an important feature for eliciting this feature. We also find that intramolecular hydrogen-bonding can induce such rigidity in amphiphile backbone. Guest encapsulation stability of these assemblies was found to be significantly altered within a narrow temperature window, which correlates with the temperature-sensitive size transition of the molecular assembly. Molecular design principles demonstrated here could have broad implications in developing future temperature-responsive systems.

SUBMITTER: Raghupathi KR

PROVIDER: S-EPMC4916844 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Influence of backbone conformational rigidity in temperature-sensitive amphiphilic supramolecular assemblies.

Raghupathi Krishna R KR Sridhar Uma U Byrne Kevin K Raghupathi Kishore K Thayumanavan S S

Journal of the American Chemical Society 20150420 16

Molecular design features that endow amphiphilic supramolecular assemblies with a unique temperature-sensitive transition have been investigated. We find that conformational rigidity in the backbone is an important feature for eliciting this feature. We also find that intramolecular hydrogen-bonding can induce such rigidity in amphiphile backbone. Guest encapsulation stability of these assemblies was found to be significantly altered within a narrow temperature window, which correlates with the ...[more]

PMID: 25893806

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