Ontology highlight
ABSTRACT:
SUBMITTER: Senevirathne C
PROVIDER: S-EPMC4921744 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Senevirathne Chamara C Embogama D Maheeka DM Anthony Thilani A TA Fouda Ahmed E AE Pflum Mary Kay H MK
Bioorganic & medicinal chemistry 20151123 1
Kinase-catalyzed protein phosphorylation is involved in a wide variety of cellular events. Development of methods to monitor phosphoproteins in normal and diseased states is critical to fully characterize cell signaling. Towards phosphoprotein analysis tools, our lab reported kinase-catalyzed labeling where γ-phosphate modified ATP analogs are utilized by kinases to label peptides or protein substrates with a functional tag. In particular, the ATP-biotin analog was developed for kinase-catalyzed ...[more]