Ontology highlight
ABSTRACT:
SUBMITTER: Chepurny OG
PROVIDER: S-EPMC4926213 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20160629
Rational assembly of small molecule libraries for purposes of drug discovery requires an efficient approach in which the synthesis of bioactive compounds is enabled so that numerous structurally related compounds of a similar basic formulation can be derived. Here, we describe (4 + 3) and (3 + 2) indole annulation strategies that quickly generate complex indole heterocycle libraries that contain novel cyclohepta- and cyclopenta[b]indoles, respectively. Screening of one such library comprised of ...[more]