Ontology highlight
ABSTRACT:
SUBMITTER: Silvi M
PROVIDER: S-EPMC5900874 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Chemistry (Weinheim an der Bergstrasse, Germany) 20180228 17
Furan- and indole-derived boronate complexes react with alkyl iodides under radical (photoredox) or polar (S<sub>N</sub> 2) conditions to generate three-component alkylation products with high efficiency and complete stereospecificity. The methodology allows the incorporation of versatile functional groups such as nitriles, ketones, esters, sulfones, and amides, providing rapid access to complex chiral heteroaromatic molecules in enantioenriched form. Interestingly, while indolyl boronate comple ...[more]