Ontology highlight
ABSTRACT:
SUBMITTER: Ohrvik H
PROVIDER: S-EPMC4933151 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Öhrvik Helena H Logeman Brandon B Turk Boris B Reinheckel Thomas T Thiele Dennis J DJ
The Journal of biological chemistry 20160503 27
Copper is an essential metal ion for embryonic development, iron acquisition, cardiac function, neuropeptide biogenesis, and other critical physiological processes. Ctr1 is a high affinity Cu(+) transporter on the plasma membrane and endosomes that exists as a full-length protein and a truncated form of Ctr1 lacking the methionine- and histidine-rich metal-binding ectodomain, and it exhibits reduced Cu(+) transport activity. Here, we identify the cathepsin L/B endolysosomal proteases functioning ...[more]