Ontology highlight
ABSTRACT:
SUBMITTER: Handa S
PROVIDER: S-EPMC4966530 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Handa Sachin S Andersson Martin P MP Gallou Fabrice F Reilly John J Lipshutz Bruce H BH
Angewandte Chemie (International ed. in English) 20160229 16
The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Comparisons with existing state-of-the-art ligands and catalysts are discussed herein. ...[more]