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Sustainable ppm level palladium-catalyzed aminations in nanoreactors under mild, aqueous conditions.

ABSTRACT: A 1?:?1 Pd?:?ligand complex, [t-BuXPhos(Pd-?-cinnamyl)]OTf, has been identified as a highly robust pre-catalyst for amination reactions leading to diarylamines, where loadings of metal are typically at 1000 ppm Pd, run in water at temperatures between rt and 45 °C. The protocol is exceptionally simple, is readily scaled, and compares very favorably vs. traditional amination conditions. It has also been shown to successfully lead to key intermediates associated with several physiologically active compounds.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC7020654 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Sustainable ppm level palladium-catalyzed aminations in nanoreactors under mild, aqueous conditions.

Zhang Yitao Y Takale Balaram S BS Gallou Fabrice F Reilly John J Lipshutz Bruce H BH

Chemical science 20190920 45

A 1 : 1 Pd : ligand complex, [<i>t</i>-BuXPhos(Pd-π-cinnamyl)]OTf, has been identified as a highly robust pre-catalyst for amination reactions leading to diarylamines, where loadings of metal are typically at 1000 ppm Pd, run in water at temperatures between rt and 45 °C. The protocol is exceptionally simple, is readily scaled, and compares very favorably <i>vs.</i> traditional amination conditions. It has also been shown to successfully lead to key intermediates associated with several physiolo ...[more]

PMID: 32110341

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