Ontology highlight
ABSTRACT:
SUBMITTER: Torres-Campana D
PROVIDER: S-EPMC7058283 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Torres-Campana Daniela D Kimura Shuhei S Orsi Guillermo A GA Horard Béatrice B Benoit Gérard G Loppin Benjamin B
PLoS genetics 20200305 3
Following fertilization of a mature oocyte, the formation of a diploid zygote involves a series of coordinated cellular events that ends with the first embryonic mitosis. In animals, this complex developmental transition is almost entirely controlled by maternal gene products. How such a crucial transcriptional program is established during oogenesis remains poorly understood. Here, we have performed an shRNA-based genetic screen in Drosophila to identify genes required to form a diploid zygote. ...[more]