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Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals.

ABSTRACT: A cooperative catalytic strategy of chiral iminium catalysis by regioselective activation of the C=C bond in enals and a transition metal promoting to open the 2-vinylcyclopropanes for highly regio- and enantioselective [3 + 2] cycloaddition reaction of 2-vinylcyclopropanes with ?,?-unsaturated aldehydes has been developed.

SUBMITTER: Zhu H

PROVIDER: S-EPMC4979765 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals.

Zhu Haipan H Du Peile P Li Jianjun J Liao Ziyang Z Liu Guohua G Li Hao H Wang Wei W

Beilstein journal of organic chemistry 20160629

A cooperative catalytic strategy of chiral iminium catalysis by regioselective activation of the C=C bond in enals and a transition metal promoting to open the 2-vinylcyclopropanes for highly regio- and enantioselective [3 + 2] cycloaddition reaction of 2-vinylcyclopropanes with α,β-unsaturated aldehydes has been developed. ...[more]

PMID: 27559383

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