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New variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion.

ABSTRACT: We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing followed by RT-PCR and direct sequencing revealed two types of fusion transcripts between exon 1B of IRF2BP2 and exon 3 of RARA. The patient received all-trans retinoic acid and conventional chemotherapy, but showed resistance. This is the second report of IRF2BP2 involvement in APL, and we describe various breakpoints for the IRF2BP2-RARA fusion gene.

SUBMITTER: Shimomura Y

PROVIDER: S-EPMC4982591 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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New variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion.

Shimomura Yoshimitsu Y Mitsui Hideki H Yamashita Yukiko Y Kamae Tsuyoshi T Kanai Akinori A Matsui Hirotaka H Ishibashi Tomohiko T Tanimura Akira A Shibayama Hirohiko H Oritani Kenji K Kuyama Jun J Kanakura Yuzuru Y

Cancer science 20160801 8

We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing followed by RT-PCR and direct sequencing revealed two types of fusion transcripts between exon 1B of IRF2BP2 and exon 3 of RARA. The patient received all-trans retinoic acid and conve ...[more]

PMID: 27193600

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