Ontology highlight
ABSTRACT:
SUBMITTER: Shimomura Y
PROVIDER: S-EPMC4982591 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Shimomura Yoshimitsu Y Mitsui Hideki H Yamashita Yukiko Y Kamae Tsuyoshi T Kanai Akinori A Matsui Hirotaka H Ishibashi Tomohiko T Tanimura Akira A Shibayama Hirohiko H Oritani Kenji K Kuyama Jun J Kanakura Yuzuru Y
Cancer science 20160801 8
We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing followed by RT-PCR and direct sequencing revealed two types of fusion transcripts between exon 1B of IRF2BP2 and exon 3 of RARA. The patient received all-trans retinoic acid and conve ...[more]