Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC5007193 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Tang Yi Y Feinberg Tamar T Keller Evan T ET Li Xiao-Yan XY Weiss Stephen J SJ
Nature cell biology 20160801 9
Bone-marrow-derived skeletal stem/stromal cell (SSC) self-renewal and function are critical to skeletal development, homeostasis and repair. Nevertheless, the mechanisms controlling SSC behaviour, particularly bone formation, remain ill-defined. Using knockout mouse models that target the zinc-finger transcription factors Snail or Slug, or Snail and Slug combined, a regulatory axis has been uncovered wherein Snail and Slug cooperatively control SSC self-renewal, osteoblastogenesis and bone forma ...[more]