Ontology highlight
ABSTRACT:
SUBMITTER: Galletta BJ
PROVIDER: S-EPMC5007297 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Galletta Brian J BJ Fagerstrom Carey J CJ Schoborg Todd A TA McLamarrah Tiffany A TA Ryniawec John M JM Buster Daniel W DW Slep Kevin C KC Rogers Gregory C GC Rusan Nasser M NM
Nature communications 20160825
The centrosome is the major microtubule-organizing centre of many cells, best known for its role in mitotic spindle organization. How the proteins of the centrosome are accurately assembled to carry out its many functions remains poorly understood. The non-membrane-bound nature of the centrosome dictates that protein-protein interactions drive its assembly and functions. To investigate this massive macromolecular organelle, we generated a 'domain-level' centrosome interactome using direct protei ...[more]